Skin is the Source of Infection

The skin is not a flat, level surface, it is a complex organ (5,7) We know that a major source of healthcare-associated infections (HAIs) is bacteria on the patient’s own skin (2,4)

Available from Iskus Health in

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    Republic of Ireland
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    Northern Ireland

Patient Preoperative Skin Preparation

ChloraPrep™ is a rapid-acting, persistent, and broad-spectrum antiseptic for a range of minor and major medical procedures. The 2% Chlorhexidine Gluconate/70% Isopropyl Alcohol formulation acts fast on a broad spectrum of bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), and keeps fighting bacteria for at least 48 hours. Together, the formulation and applicator provide a proven system that supports infection control guidelines for helping to reduce the incidence of blood stream infections (BSI) and surgical site infections (SSI). Together, the formulation and single use applicator reduce microorganisms on the skin.

…and its more than just a 2%CHG 70%IPA solution

ChloraPrep is superior compared to traditional iodophors

  • Rapid acting: The 70% isopropyl alcohol in ChloraPrep rapidly kills microorganisms versus free iodine, which requires two minutes to begin antimicrobial activity.
  • Persistent: ChloraPrep maintains antimicrobial activity for at least 48 hours compared to two hours for free iodine
  • Broad spectrum: ChloraPrep antimicrobial activity is effective against microorganisms including gram-positive and gram-negative bacteria, Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococci(VRE), Clostridium difficile, Acinetobacter, and most viruses and fungi.
  • Active in protein-rich biomaterials: Remains active in the presence of blood, serum, and other protein-rich biomaterials unlike traditional iodophors, which are neutralized.
Prescribing Information
ChloraPrep® & ChloraPrep with Tint 2% chlorhexidine gluconate w/v/ 70% isopropyl alcohol v/v cutaneous solution. Refer to the  Summary of Product Characteristics before prescribing.  Presentation: ChloraPrep – each applicator contains 0.67ml, 1.5ml,  3ml, 10.5ml or 26ml of 20 mg/ml chlorhexidine & 0.70 ml/ml  isopropyl alcohol; ChloraPrep with Tint – each applicator contains  3ml, 10.5ml or 26ml of 20 mg/ml chlorhexidine & 0.70 ml/ml  isopropyl alcohol. Indication: Disinfection of skin prior to invasive  medical procedures. Dosage & administration: Applicator volume  dependent on invasive procedure being undertaken. May be used  for all age groups and patient populations. Use with care in newborn  babies and those born prematurely. Applicator squeezed to break  ampoule and release antiseptic solution onto sponge. Solution  applied by gently pressing sponge against skin and moving back  and forth for 30 seconds. The area covered should be allowed to air  dry. Contra-indications: Patients with known hypersensitivity to  ChloraPrep or ChloraPrep with Tint or any of its components,  especially those with a history of possible Chlorhexidine-related  allergic reactions. Warnings and precautions: Solution is  flammable. Do not use with ignition sources until dry. Do not use in  excessive quantities, allow to pool in patient skin folds or drip on  materials in contact with patient skin. Remove any soaked materials  before proceeding with the intervention. Ensure no excess product is  present prior to application of occlusive dressing. For external use  only on intact skin, do not use on open skin wounds or broken or  damaged skin. Over-vigorous use on fragile or sensitive skin or  repeated use may lead to local skin reactions. Avoid prolonged skin  contact. Avoid contact with eyes, mucous membranes, middle ear  and neural tissue. Chlorhexidine may induce hypersensitivity,  including generalised allergic reactions and anaphylactic shock.  May cause chemical burns in neonates, with a higher risk in preterm  infants and within the first 2 weeks of life. Pregnancy & lactation:  Although no studies have been conducted, no effects are  anticipated as systemic exposure is negligible. Undesirable  effects: Very rare; allergic or irritation skin reactions to chlorhexidine,  isopropyl alcohol or sunset yellow (E110, present in ChloraPrep with  Tint only), including erythema, rash, pruritus and blisters or  application site vesicles, other local symptoms have included skin  burning sensation, pain and inflammation. Frequency not known;  hypersensitivity including anaphylactic shock, dermatitis, eczema,  urticaria, chemical burns in neonates. Discontinue use at the first  sign of local skin reaction. Per applicator costs (ex VAT) ChloraPrep:  0.67ml (SEPP) – UK £0.30, Ireland €0.39; 1.5ml (FREPP) – UK £0.55, Ireland €0.64; 1.5ml – UK £0.78, Ireland €0.94; 3ml; 3ml – UK £0.85,  Ireland 1.06; 10.5ml – UK £2.92, Ireland €3.79; 26ml – UK £6.50,  Ireland €7.96. ChloraPrep with Tint: 3ml – UK £0.89, Ireland €1.09;  10.5ml – UK £3.07, Ireland €3.88; 26ml – UK £8.18, Ireland €8.19.  Legal category: GSL. Marketing Authorisation Numbers:  ChloraPrep, (UK: PL31760/0004; Ireland: PA1435/001/002) &  ChloraPrep with Tint, (UK: PL31760-0001; Ireland:  PA1435/001/001). Marketing Authorisation Holder: CareFusion  UK 244 Ltd, The Crescent, Jays Close, Basingstoke, Hampshire,  RG22 4BS. Date of Preparation: December 2016.
1. Silva P. J Perioper Pract 2013; 23(4): 87-90.
2. McGrath DR, McCrory D. Ann R Coll Surg Engl 2005; 87(5):366-8.
3. El-Othmani MM et al. Int Surg J 2016; 3(1): 1-10.
4. MHRA. Public Assessment Report 2012: UK/H/1305/02/DC.
4.1. Gahlot R et al. Int J Crit Illn Inj Sci 2014; 4(2): 162-7.
5. Inwood S. Br J Nurs 2007; 16(22): 1390-4.
7. Moureau NL. Outpatient Surgery Online 2010; May: 31-3.
8. Fredricks DN. J Invest Dermatol Symp Proc 2001; 6(3): 167-9.